Table 3.
MUC5B rs35705950 genotype in white subjects with severe COVID-19 and controls.
| Discovery | Validation | Replication I | Replication II | |||||
|---|---|---|---|---|---|---|---|---|
| COVID-19 | Controls | COVID-19 | Controls | COVID-19 | Controls | COVID-19 | Controls | |
| Country | Netherlands | Netherlands | United Kingdom | United Kingdom | Italy | Italy | Spain | Spain |
| N | 83 | 611 | 436 | 356,735 | 835 | 1,255 | 775 | 950 |
| GG, n (%) | 76 (92) | 501 (82) | 369 (85) | 281,333 (79) | 670 (80) | 964 (77) | 624 (81) | 723 (76) |
| GT, n (%) | 7 (8) | 103 (17) | 67 (15) | 70,987 (20) | 156 (19) | 268 (21) | 140 (18) | 210 (22) |
| TT, n (%) | 0 (0) | 7 (1) | 0 (0) | 4,415 (8) | 9 (1) | 23 (2) | 11 (1) | 17 (2) |
| MAF | 0.04 | 0.10 | 0.08 | 0.11 | 0.10 | 0.13 | 0.10 | 0.13 |
| OR | 0.42 | 0.66 | 0.81 | 0.79 | ||||
| 95% CI | 0.19–0.91 | 0.51–0.85 | 0.67–0.99 | 0.64–0.98 | ||||
| p | 0.023 | 0.001 | 0.039 | 0.030 | ||||
N, number; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.