Table 2.

Regression analyses to assess the association between TX/CA and genetic mutations in patients with HeFH after propensity score matching

Characteristics	No mutation	LDLR (−)	LDLR (+)
Model 1 ORs	1 (Reference)	0.827 (0.222–3.077)	3.978 (1.980–7.989)
p value		0.776	< 0.001
Model 2 ORs	1 (Reference)	0.810 (0.217–3.021)	4.193 (2.060–8.534)
p value		0.754	< 0.001
Model 3 ORs	1 (Reference)	0.919 (0.190–4.451)	3.493 (1.442–8.465)
p value		0.917	0.006

Model 1 unadjusted, model 2 age- and sex- adjusted, model 3 fully adjusted for age, sex, BMI, CAD, smoking, hypertension, DM, family history of CAD, uncontrolled LDL-C levels, lipid-lowering therapy, total cholesterol year score and LDL cholesterol year score. Bold values indicate statistical significance

LDLR: low-density lipoprotein receptor; LDLR (−): LDLR negative mutation; LDLR (+): LDLR positive mutation; OR: odds ratio; BMI: body mass index; CAD: coronary artery disease; DM: diabetes mellitus