Table 3.
Cox Regression Models in predicting cardiovascular outcomes according to physical signs
| CVEs | Events, n/total | Hazard ratio (95% CI) | |
|---|---|---|---|
| Crude model | Adjusted model | ||
| Non-TX/CA | 24/200 | 1 (reference) | 1 (reference) |
| TX/CA | 11/50 | 2.86 (1.37–5.98)** | 2.75 (1.04–7.26)* |
| Group1 TX/CA (−) Mu (−) | 12/108 | 1 (reference) | 1 (reference) |
| Group2 TX/CA (−) Mu (+) | 12/92 | 1.07 (0.48–2.39) | 0.82 (0.34–1.98) |
| Group3 TX/CA (+) Mu (−) | 1/14 | 1.01 (0.13–7.89) | 1.02 (0.12–8.49) |
| Group4 TX/CA (+) Mu (+) | 10/36 | 3.66 (1.55–8.64)** | 3.34 (1.04–10.72)* |
Adjusted model was adjusted for age, sex, BMI, CAD, smoking, hypertension, DM, family history of CAD, adjusted LDL-C levels, lipid-lowering therapy, LDL cholesterol year score and total cholesterol year score
TX: tendon xanthomas; CA: corneal arcus; Mu: mutation; Mu (+), mutation positive; Mu (−), mutation negative
*p < 0.05, **p < 0.01