Fig. 1.

Schematic diagram of the animal experimental. Animals were allocated to three groups: Control group (Ctl), Dox-receiving group (Dox), and LLL treatment group (Dox + LLL). In Dox-treat animals, Dox (3 mg/kg) was injected by intraperitoneal injection per week ( total 4 weeks study period, accumulated dosage: 12 mg/ kg). In LLL-exposed animals, the laser was applied 10 min per point, 1 time per day, and 7 days per week. On the first day of the 1st, 2nd, 3rd and 4th week, after 2 h of LLL irradiation, Dox was injected by i.p. injections. Samples were collected on the last day of this 4-weeks experimental