Table 2.
The risk factors for hospital mortality in univariate logistic regression analysis among SCAP patients with T2DM in training set
| Variables | Survival (n = 568) | Death (n = 315) | OR (95%CI) | P value |
|---|---|---|---|---|
| Age | 65 (53.74) | 71 (59.79) | 1.202 (1.089, 1.328) (per increased 10 years old) | < 0.001 |
| Number of comorbidities | ||||
| 0 | 369 (65) | 110 (34.9) | Ref | |
| 1 | 159 (28) | 134 (42.5) | 2.827 (2.067, 3.867) | < 0.001 |
| 2 | 38 (6.7) | 61 (19.4) | 5.385 (3.408, 8.510) | < 0.001 |
| ≥ 3 | 2 (0.4) | 10 (3.2) | 16.773 (3.621, 77.695) | < 0.001 |
| Diabetes-related complications | ||||
| 0 | 504 (88.7) | 247 (78.4) | Ref | |
| 1 | 56 (9.9) | 43 (13.7) | 1.567 (1.024, 2.398) | 0.039 |
| ≥ 2 | 8 (1.4) | 25 (7.9) | 6.377 (2.835, 14.342) | < 0.001 |
| Cough | ||||
| No | 435 (76.6) | 190 (60.3) | Ref | |
| Yes | 133 (23.4) | 125 (39.7) | 2.152 (1.598, 2.898) | < 0.001 |
| Dyspnea | ||||
| No | 499 (87.9) | 238 (75.6) | Ref | |
| Yes | 69 (12.1) | 77 (24.4) | 2.340 (1.633, 3.353) | < 0.001 |
| Blood pressure (mmHg) | ||||
| ≥ 90/60 | 479 (84.3) | 201 (63.8) | Ref | |
| < 90/60 | 89 (15.7) | 114 (36.2) | 3.052 (2.211, 4.214) | < 0.001 |
| Heart rate (beat/min) | ||||
| < 100 | 332 (58.5) | 145 (46) | Ref | |
| ≥ 100 | 236 (41.5) | 170 (54) | 1.649 (1.250, 2.177) | < 0.001 |
| CRP (mg/L) | ||||
| < 10 | 199 (35) | 24 (7.6) | Ref | |
| 10–99 | 234 (41.2) | 106 (33.7) | 3.756 (2.320, 6.080) | < 0.001 |
| 100–199 | 97 (17.1) | 78 (24.8) | 6.668 (3.972, 11.191) | < 0.001 |
| ≥ 200 | 38 (6.7) | 107 (34) | 23.348 (13.304, 40.975) | < 0.001 |
| NLR | ||||
| < 7 | 317 (55.8) | 86 (27.3) | Ref | |
| 7–19 | 226 (39.8) | 142 (45.1) | 2.316 (1.686, 3.182) | < 0.001 |
| ≥ 20 | 25 (4.4) | 87 (27.6) | 12.827 (7.745,21.246) | < 0.001 |
| BNP (pg/mL) | ||||
| < 500 | 365 (64.3) | 58 (18.4) | Ref | |
| 500–4999 | 149 (26.2) | 123 (39) | 5.195 (3.604, 7.489) | < 0.001 |
| ≥ 5000 | 54 (9.5) | 134 (42.5) | 15.616 (10.259, 23.772) | < 0.001 |
| Lactate (mmol/L) | ||||
| < 1 | 213 (37.5) | 50 (15.9) | Ref | |
| 1–1.6 | 244 (43) | 85 (27) | 1.484 (1.00, 2.202) | 0.05 |
| ≥ 1.7 | 111 (19.5) | 180 (57.1) | 6.908 (4.685, 10.186) | < 0.001 |
| Platelet (×109/L) | ||||
| ≥ 100 | 463 (81.5) | 215 (68.3) | Ref | |
| < 100 | 105 (18.5) | 100 (31.7) | 2.051 (1.492, 2.819) | < 0.001 |
| Procalcitonin (µg/L) | ||||
| < 0.5 | 349 (61.4) | 146 (46.3) | Ref | |
| 0.5–1.9 | 112 (19.7) | 77 (24.4) | 1.643 (1.160,2.329) | 0.005 |
| ≥ 2 | 107 (18.8) | 92 (29.2) | 2.055 (1.464,2.885) | < 0.001 |
| APTT (s) | ||||
| < 37 | 402 (70.8) | 199 (63.2) | Ref | |
| ≥ 37 | 166 (29.2) | 116 (36.8) | 1.412(1.054,1.890) | 0.021 |
| AST (IU/L) | ||||
| < 35 | 333 (58.6) | 161 (51.1) | Ref | |
| ≥ 35 | 235 (41.4) | 154 (48.9) | 1.355 (1.028, 1.788) | 0.031 |
| Creatinine (µmol/L) | ||||
| < 100 | 362(63.7) | 173(54.9) | Ref | |
| ≥ 100 | 206(36.3) | 142(45.1) | 1.442(1.090,1.909) | 0.010 |
| BUN (mmol/L) | ||||
| < 7 | 253 (44.5) | 90 (28.6) | Ref | |
| ≥ 7 | 315 (55.5) | 225 (71.4) | 2.008 (1.495, 2.697) | < 0.001 |
Data are shown as median with number with percentage for categorical variables
SCAP Severe community-acquired pneumonia, n numbers, OR odds ratio, 95% CI 95% confidence interval, CRP C-reactive protein, NLR neutrophil to lymphocyte ratio, BNP brain natriuretic peptide, APTT activated partial thromboplastin time, AST aspartate aminotransferase, BUN blood urea nitrogen, Ref reference