Table 4.

Multivariable regression of variables associated with severe pain^b in survivors of head and neck cancer (n = 489)^c

Variablea	Odds ratio	95% Confidence interval		P value
		Lower	Upper
Recurrent disease
No	1.000
Yes	6.779	1.445	31.801	0.015
Chemotherapy
No	1.000
Yes	6.005	2.104	17.142	0.001
Depression risk
(1) No risk	1.000			REF
(2) Mild-moderate risk	5.306	2.202	12.783	< 0.001
(3) Major risk	8.002	2.672	23.967	< 0.001

^aVariables entered were age (years), sex, location of malignancy, recurrent disease, chemotherapy, radiotherapy, surgery, osteoarthritis, emphysema and lung disease, neuropathic pain, and depression risk

^bScore of 8 to 10 according to the 2019 National Comprehensive Cancer Network guidelines

^cComplete case analysis