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. 2021 Dec 7;18:57. doi: 10.1186/s12987-021-00285-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Comparison of CSF/plasma concentration ratios (%) for lithium and passive permeability markers. A Following acute exposure (for lithium: n = 3–10 postnatal animals, n = 1 adult; data from Fig. 4) and B long-term exposure in rats at different stages of development (n = 1–3 postnatal animals, n = 2 adult; data from Fig. 5. CSF/plasma ratios are plotted against the molecular radius of the markers. The curves were fitted to the data for the passive markers using single phase exponential decay non-linear regression analysis with the maximum constrained to 100% (Graphpad Prism). Note lithium values for comparison with P20 diffusion data are from P16 animals. Each point represents the average CSF/plasma ratio (%) for each age within each treatment group. Permeability data for markers other than lithium from [39].