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. 2021 Dec 5;8(1):e000569. doi: 10.1136/lupus-2021-000569

Figure 2.

Figure 2

Expression pattern of NEU1 in the kidneys of 58 patients with proliferative LN. (A) Immunohistochemical staining of NEU1 in the glomeruli (above) and tubulointerstitium (below) areas of patients with proliferative LN and NC samples. (B) Mean optical density of NEU1 in the glomeruli area of 42 patients with proliferative LN with CI ≥1, 16 patients with proliferative LN with CI=0 and 10 NC samples. (C) Mean optical density of NEU1 in the tubulointerstitium area of 42 patients with proliferative LN with CI ≥1, 16 patients with proliferative LN with CI=0 and 10 NC samples. (D) Co-localisation of NEU1 (red) and integrin-α (green) (marker of mesangial cell), CD31 (green) (marker of endothelial cells), NPSH2 (green) (marker of podocyte) or LTL (green) (marker of proximal tubule cells). Scale bar: 50 µm. CI, chronicity index; DAPI, 4′,6-diamidino-2-phenylindole; LN, lupus nephritis; LTL, Lotus Tetragonolobus Lecti; NC, normal control; NEU1, neuraminidase 1; NPHS2, NPHS2 stomatin family member, podocin.