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. 2021 Dec 6;9(12):e003334. doi: 10.1136/jitc-2021-003334

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Differential taxa were enriched in the CBR group and NCB group of the 65 patients with hepatobiliary cancers. (A) PCoA showed the beta diversity evaluated by Bray-Curtis distance between the CBR group and NCB group. (B) Common and unique taxa at the specie level between the CBR group and NCB group. (C) Taxonomic cladogram from LEfSe showed different taxa enriched in the CBR group and NCB group (LDA>3, p<0.05). (D) LEfSe identified significantly differentially abundant taxa in the CBR group and NCB group (LDA>3, p<0.05). CBR, clinical benefit response; LEfSe, linear discriminant analysis effect size; LDA, linear discriminant analysis; NCB, non-clinical benefit; PCoA, principal coordinate analysis.