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. 2021 Dec 6;9(12):e003334. doi: 10.1136/jitc-2021-003334

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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The gut microbiome distribution was affected by clinical factors. (A) RDA with permutation test showed the clinical factors associated with the distribution of patients with hepatobiliary cancers. (B) RDA with permutation test showed the clinical factors associated with the different taxa enriched in the CBR group and NCB group. (C) Relative abundance comparison of Eubacterium hallii in patients with large tumors (≥5 cm) and small tumors (≥5 cm) (Wilcoxon test). (D) Relative abundance comparison of the Clostridium genus in patients with elevated bile acid and normal bile acid (Wilcoxon test). CBR, clinical benefit response; ECOG-PS, Eastern Cooperative Oncology Group performance status; NCB, non-clinical benefit; RDA, redundancy analysis.