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. 2021 Dec 7;19:409. doi: 10.1186/s12951-021-01157-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Fabrication and characterization of nanocomposite hydrogel. a Schematic representation of construction of nanocomposite hydrogel. b TEM of gel in different concentration (1% and 2%, w/v) c The size distribution and TEM image of TP@HSA NPs. d Macroscopic images,SEM and images of injection through needle showing of blank gel and nanocomposite hydrogel. e Strain-dependent oscillatory shear rheology of blank gel and nanocomposite hydrogel. f Step-shear measurements of blank gel and nanocomposite hydrogel over two cycles with alternating high shear (100 s⁻¹) and low shear (0.05 s⁻¹) rates. g Release profile of CCPA from nanocomposite hydrogel. h Release profile of TP from TP@HSA NPs in different pH and nanocomposite hydrogel