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. 2021 Dec 7;19:409. doi: 10.1186/s12951-021-01157-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Analgesic and anti-inflammatory effects of ST36 nanocomposite hydrogel. a The schematic diagram of experiment procedure. b Mechanical allodynia (paw withdrawal latency in grams) among the different groups. c Thermal hyperalgesia (paw withdrawal threshold in seconds) among four groups. d Photographs of representative mice hand paws among the six groups. (Normal: healthy mice treated with saline, Model: AIA mice treated with saline, G1: ST36 TP-CCPA-solution, G2: ST36 TP-CCPA-Gel, G3: ST36 TP@HSA NPs-CCPA-Gel, G4: Non-acupoint TP@HSA NPs-CCPA-Gel) e–g Hind paw thickness, volume, and arthritis scores changes of the mice. Data (means ± SD) shown are pooled from two independent experiments with similar results. (n = 6, *p < 0.05, **p < 0.01, and ***p < 0.001)