Weight (A), percent fat mass (B), and lean mass (C) of NMD (n=7), HFD (n=7), HFD+Atr (n=5), and HFD+Bos (n=6) mice fed NMD or HFD, measured on weeks 0, 4, 8, and 10. Total water was measured through weeks 8 and 10 (D). Food (kcal/day) (E) and water intake (ml/day) (F) was measured daily. (A–D) were analyzed by two-way ANOVA, and panels (E,F) were analyzed by one-way ANOVA with post-hoc Tukey’s test between individual groups. Data are expressed as mean ± SEM.