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. Author manuscript; available in PMC: 2022 Jul 30.
Published in final edited form as: Clin Sci (Lond). 2021 Jul 30;135(14):1773–1789. doi: 10.1042/CS20210549

Figure 5. ET-1 receptor blockade improves hypoadiponectinemia in mice fed a HFD.

Figure 5.

Plasma adiponectin was analyzed via ELISA after 10 weeks on diet and 2 weeks of treatment with atrasentan or bosentan (A). Gene expression of AdipoQ, Pparγ, Adipsin/Cfd, Retn, and Leptin from eWAT of mice after 10 weeks on diet and 2 weeks of treatment with atrasentan or bosentan were determined via ddPCR (B–F) (n=5 per group). Data were analyzed by one-way ANOVA with Tukey’s post-hoc test for individual groups. Data are expressed as mean ± SEM. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.