. 2019 Sep 2;20(11):1557–1571. doi: 10.1111/obr.12921

Table 3.

Findings for interaction between genetic variants and change in leisure time physical activity or physical activity in relation to T2D incidence

Genetic variants which showed interaction with LTPA in DPS:

ABCC8 rs3758947; ADRA2B 12Glu9; PPARG rs17036314, rs1801282; SLC2A2 rs5393, rs5394, rs5404;

Loci of genetic variants which showed no interaction with LTPA in DPS:

ABCC8 (3), ADRB2 (1), ADRB3 (1), GHRL (6), IGF1R (1), IL6 (1), KCNJ11 (1), LEPR (3), LIPC (1), TNF (1), PPARG (1), SLC2A2 (1)

Genetic variants which showed interaction with PA in cohort studies:

HNF1B rs4430796^a, IRS1 rs1522813^b, T2D‐GRS (65)^c, IR‐GRS (SNPs of four genes)^c, FI‐GRS (SNPs of nine genes)^c

Loci of genetic variants which showed no interaction with PA in cohort studies:

PPARD (9)^d, PPARGC (9)^d, T2D‐GRS (14)^d, T2D‐GRS (36)^d, T2D‐GRS (SNPs of 49 genes)^e, FG‐GRS (36)^c, BC‐GRS (SNPs of nine genes)^c, 65 T2D SNPs^c, 16 T2D SNPs^a

Numbers in brackets indicate the numbers of investigated SNPs.

Malmö Preventive Project.

Nurses' Health Study/Health Professionals Follow‐Up Study.

Atherosclerosis Risk in Communities study.

Shanghai Diabetes GWAS Study.

InterAct.

Abbreviations: BC, beta cells; DPS, Diabetes Prevention Study; FG, fasting glucose; FI, fasting insulin; GRS, gene risk score; IR, insulin resistance; LTPA, leisure‐time physical activity; PA, physical activity; SDGS, Shanghai Diabetes GWAS Study; T2D, type 2 diabetes mellitus.