Table 4.
Findings for interaction between genetic variants and lifestyle intervention for weight reduction in relation to T2D incidence
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Genetic variants which showed interaction in DPS: ADRA2B 12Glu9, LIPC rs2070895, PPARG rs1152003, TNFα rs1800629, and with trend CDKN2A/B rs10811661 Loci of genetic variants which showed no interaction in DPS: ABCG8 (1), ADAMTS9 (1), ADIPOQ (5), ADIPOR2 (3), ADRB3 (1), CDC123 (1), CDKN2B (1), FTO (1), IGF2BP2 (1), IL‐6 (1), JAZF1 (1), KCNQ1 (1), LEPR (3), MTNR1B (1), NOTCH2 (1), PPARG (1), THADA (1), TSPAN8 (1), GRS based on 19 SNPs of T2D‐associated loci |
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Genetic variants which showed interaction in DPP: ADIPOR2 rs758027, ENPP1 rs1044498, MC4R rs17066829 and with trend ADIPOQ rs17373414 Loci of genetic variants which showed no interaction in DPP: ABCC8 (83), ACE (1), ADIPOQ (19), ADIPOR1 (22), ADIPOR2 (26), ATM (1), CAPN10 (33), CASQ1 (2), CDKAL1 (1), CREB1 (13), CYP3A4 (15), EXT2 (3), FOXO1 (34), GCG (13), GCK (37), GCKR (3), HNF1A (20), HNF1B (73), HNF4A (66), IRS1 (2), IGF2BP2 (1); ITLN1 (11), ITLN2 (15), KCNJ11 (9), KCNQ1 (1), LIPC (1), LOC387761 (1), MC4R (21), MEF2A (38), MEF2D (16), NEUROD1 (14), NOS3 (6), PCK1 (37), PCK2 (14), PDX1 (13), PKLR (10), PPARA (63), PPARG (59), PRKAG3 (11), PPARGC1A (79), PPARGC1B (96), PRKAA1 (9), PRKAA2 (18), PRKAB1 (10), PRKAB2 (13), PRKAG1 (7), PRKAG2 (53), PTPN1 (27), SLC22A1 (47), SLC22A2 (44), SLC30A8 (61), SLC47A1 (29); STK11 (10), TNF (1), WFS1 (2), GRS based on 34 T2D‐associated loci |
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Genetic variants which showed no interaction in DPS and DPP: ADIPOQ (5), ADIPOR2 (5), CDKAL1 rs7754840, HHEX rs1111875, HNF1B rs757210, KCNJ11 rs5219a ; PPARG rs1801282; SLC30A8 rs13266634; TCF7L2 rs7903146a, rs12255372a, WFS1 rs10010131 |
Numbers in brackets indicate the numbers of investigated SNPs.
Variants which showed no interaction but different associations in lifestyle strata.
Abbreviations: DPP, Diabetes Prevention Program; DPS, Diabetes Prevention Study; GRS, gene risk score; T2D, type 2 diabetes mellitus.