FIGURE 2.

A model of the generation of p52 from p100. In the resting cells, p100 forms high molecular weight complexes known as kappaBsomes; it inhibits nearly all NF-κB subunits. Upon stimulation, p100 will be degraded resulting in the early induction of NF-κB which in term activates nfκb2 gene itself. The newly synthesized p100 protein gets phosphorylated at the C-terminal serine residues, then it is ubiquinated and processed into p52 which heterodimer with RelB and regulate its target genes. Other possible modes of p100 processing are not shown here.