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. 2021 Nov 23;9:764164. doi: 10.3389/fcell.2021.764164

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Copyright © 2021 Ghosh and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abnormal products of nfκb2 gene. (A) The nfκb2 gene is involved in lymphoma-associated chromosomal translocation. Coding exons are represented by color filled boxes. (B) Truncated nfκb2 genes code for C-terminal truncated protein variants lacking different portions of the ankyrin domain, named p52-X. (C) Oncogenic p52-X:RelA heterodimer preferentially binds to unfavorable κB site. (D) Table showing the missense mutants in the dimerization domain of p52 and the corresponding caner types.