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. 2021 Nov 23;12:727300. doi: 10.3389/fimmu.2021.727300

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Copyright © 2021 Silva, Sundling, Folkesson, Fröberg, Nobrega, Canto-Gomes, Chambers, Lakshmikanth, Brodin, Bruchfeld, Nigou, Correia-Neves and Källenius

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall effect of stimulation on cytokine production from individuals with active- and latent TB and healthy controls. Average number of cytokine⁺ cells following 24 h of stimulation with LAM, PIM, or PPD of PBMCs from individuals with active TB (ATB), latent TB (LTB), or healthy controls (HC) among (A) CD3⁺ T cells, (B) CD3^–CD7⁺ NK cells, (C) CD20⁺ B cells, and (D) CD33⁺ myeloid cells. The groups average number of cytokine-producing cells were compared using the Friedman test followed by Dunn’s posttest. *p<0.05, **p<0.01, ***p<0.001.