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. 2021 Nov 23;12:753107. doi: 10.3389/fneur.2021.753107

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Copyright © 2021 Meyer-Arndt, Schmitz-Hübsch, Bellmann-Strobl, Brandt, Haynes, Gold, Paul and Weygandt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Patient-specific HAQUAMS scores for overall HRQoL and five HAQUAMS subscales at T0 and T1 corrected for the CNI mentioned in the text. Each line depicts the trajectory of the given marker for an individual participant. The t-statistics and p-values reported characterizing the effect of time on each given parameter across all 28 PwMS. It is noted that higher scores correspond to less HRQoL, positive t-statistics to a (not necessarily significant) increase of a marker across time (and thus to a not necessarily significant HRQoL worsening).