Table 2.
List of 25 FVC Predictors for Progression Derived from COMET Training Cohort and Their Corresponding LASSO Regression Coefficient and Percentage of Tenfold CV Support (≥50% CV)
| Gene Symbol* | Gene Description | LASSO Regression Coefficient | % CV Support | Matched in Imperial Cohort† | Matched in UChicago Cohort† |
|---|---|---|---|---|---|
| CNR2 | Cannabinoid receptor 2 | −1.066 | 100 | § | ‖ |
| ITLN1 | Intelectin 1 | 3.440 | 100 | § | ‖ |
| LINC00319 | Long intergenic nonprotein coding RNA 319 | 4.758 | 100 | § | _ |
| PCDHB15 | Protocadherin β 15 | 3.521 | 100 | § | ‖ |
| RAB3C | RAB3C, RAS oncogene family | −2.218 | 100 | § | ‖ |
| MSR1 | Macrophage scavenger receptor 1 | 2.157 | 90 | § | ‖ |
| SSU72P8 | SSU72 pseudogene 8 | −1.367 | 90 | _ | _ |
| MAZ | MYC associated zinc finger protein | 2.188 | 80 | § | ‖ |
| NT5E | 5′-nucleotidase ecto | −3.361 | 80 | § | ‖ |
| PLA2G4A | Phospholipase A2 group IVA | −0.542 | 80 | § | ‖ |
| ATP6AP1L | ATPase H+ transporting accessory protein 1 like | −2.080 | 70 | § | _ |
| IGLC1 | Immunoglobulin lambda constant 1 | −0.0005 | 70 | _ | _ |
| TP63 | Tumor protein p63 | 1.710 | 70 | § | ‖ |
| ZNF252P | Zinc finger protein 252, pseudogene | −0.289 | 70 | § | ‖ |
| APTX | Aprataxin | −1.380 | 60 | § | ‖ |
| GYPA | Glycophorin A (MNS blood group) | 0.029 | 60 | § | ‖ |
| HBB | Hb subunit β | 0.037 | 60 | § | ‖ |
| PNMA5 | PNMA family member 5 | −0.942 | 60 | § | ‖ |
| RLBP1 | Retinaldehyde binding protein 1 | 0.038 | 60 | § | _ |
| FAM111B | Family with sequence similarity 111 member B | −0.601 | 50 | § | ‖ |
| GABRR1 | γ-aminobutyric acid type A receptor rho1 subunit | 0.058 | 50 | § | _ |
| GPR39 | G protein–coupled receptor 39 | 0.706 | 50 | § | _ |
| PAWR | Proapoptotic WT1 regulator | −0.515 | 50 | § | ‖ |
| PLCL1 | Phospholipase C like 1 (inactive) | 0.617 | 50 | § | † |
| RBM43 | RNA binding motif protein 43 | 0.284 | 50 | § | † |
Definition of abbreviations: COMET = Correlating Outcomes with Biochemical Markers to Estimate Time-Progression in Idiopathic Pulmonary Fibrosis; CV = cross-validation; GE = gene expression; Imperial = Imperial College London; LASSO = Logistic Least Absolute Shrinkage and Selection Operator; UChicago = University of Chicago.
Genes in FVC predictor derived from COMET training cohort. Detailed prioritization criteria are described in Figure 1A.
Genes in FVC predictor derived from COMET training cohort were mapped by “cross-GE-platform-gene-match.”
Genes mapped to Imperial cohort (details are described in Figure 1B1).
Gene mapped to UChicago cohort (details are described in Figure 1B1).