Table 4.
Tetralogy of Fallot results adjusted for maternal race/ethnicity, vitamin use, BMI, education and smoking with p-value of the interaction term <0.1 (Reference=low air pollution defined by lower two tertiles of pollutant exposure during the first two months of pregnancy and wildtype defined as the homozygous genotype with the most frequent allele among controls).
| Pollutanta | Gene symbol | dbSNP ID | Odds Ratio (95% Confidence Interval)b | ||
|---|---|---|---|---|---|
| High air pollution + gene variant | Low air pollution + gene variant | High air pollution + wildtype | |||
| CO | ABCC2 | rs717620 | 1.2 (0.3, 4.1) | 0.5 (0.2, 1.4) | 0.4 (0.2, 1.1) |
| CO | ABCC2 | rs3740066 | 0.9 (0.3, 2.5) | 0.7 (0.3, 1.7) | 0.3 (0.1, 0.9) |
| CO | CYP1A1 | rs1048943 | 0.8 (0.3, 2.5) | 0.6 (0.2, 1.6) | 0.4 (0.1, 1.1) |
| NO | CYP2A6 | rs28399433 | NC | 2.1 (0.8, 5.5) | 1.2 (0.5, 2.6) |
| NO | TPMT | rs1800460 | 2.8 (0.8, 10.1) | 0.6 (0.2, 2.7) | 0.6 (0.3, 1.4) |
| NO | UGT2B15 | rs1902023 | 1.0 (0.4, 2.6) | 0.6 (0.2, 1.3) | 0.3 (0.1, 1.1) |
| NO2 | ABCB1 | rs1045642 | 0.5 (0.2, 1.5) | 1.5 (0.7, 3.6) | 1.3 (0.4, 4.2) |
| NO2 | ABCB1 | rs1128503 | 0.5 (0.1, 1.4) | 1.3 (0.6, 3.1) | 1.4 (0.4, 4.2) |
| NO2 | ABCB1 | rs2032582 | 0.6 (0.2, 1.8) | 1.7 (0.8, 3.8) | 1.3 (0.5, 3.9) |
| NO2 | ABCC2 | rs717620 | 1.1 (0.4, 3.2) | 0.3 (0.1, 1.0) | 0.3 (0.1, 0.8) |
| NO2 | ABCC2 | rs3740066 | 0.7 (0.3, 1.7) | 0.6 (0.3, 1.2) | 0.3 (0.1, 0.9) |
| NO2 | CYP2A6 | rs4986891 | 1.4 (0.3, 7.6) | NC | 0.6 (0.3, 1.2) |
| NO2 | CYP2C19 | rs12248560 | 0.9 (0.3, 2.7) | 0.7 (0.3, 1.6) | 0.4 (0.1, 0.9) |
| NO2 | SLCO1B3 | rs4149117 | 0.3 (0.1, 1.3) | 1.5 (0.7, 3.2) | 1.0 (0.4, 2.4) |
| NO2 | UGT2B15 | rs1902023 | 0.6 (0.2, 1.5) | 0.5 (0.2, 1.2) | NC |
| PM10 | ABCB1 | rs1045642 | 0.7 (0.2, 2.1) | 1.6 (0.6, 4.1) | 2.0 (0.6, 5.9) |
| PM10 | SLC22A2 | rs316019 | 1.4 (0.4, 5.4) | NC | 0.7 (0.4, 1.5) |
| PM10 | SLCO2B1 | rs2306168 | 2.2 (0.5, 10.7) | 0.6 (0.2, 1.7) | 0.7 (0.3, 1.4) |
| PM10 | TPMT | rs1800460 | 0.6 (0.2, 2.5) | 5.3 (1.5, 18.8) | 1.2 (0.6, 2.4) |
| PM2.5 | ABCC2 | rs717620 | 1.8 (0.6, 6.0) | NC | 1.6 (0.7, 3.9) |
| PM2.5 | SLCO1B1 | rs4149056 | 5.2 (1.3, 21.0) | 0.7 (0.2, 2.2) | 1.5 (0.6, 3.6) |
| PM2.5 | UGT2B15 | rs1902023 | 2.5 (0.8, 7.9) | 0.6 (0.2, 1.9) | 0.9 (0.2, 3.4) |
a
Highest tertile cut-offs: CO= 0.730 ppm; NO=15.15 ppb; NO=20.15 ppb; PM10=38.80 μg/m3; PM2.5=19.86 μg/m3
b
Adjusted for maternal race/ethnicity, education, BMI, folate-containing vitamin use and smoking in early pregnancy
NC = not calculated (when case or control counts were <3); rows were removed if two estimates were NC