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. 2021 Dec 3;14:6523–6542. doi: 10.2147/JIR.S339670

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© 2021 Duan et al.

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VDR directly interacts with NLRP3 and inhibits NLRP3 activity by increasing NLRP3 ubiquitination level. (A) Cell lysates were immunoprecipitated (IP) and immunoblotted (IB) with the indicated antibodies in each group. (B) Colocalization of VDR and NLPR3 in synovial sections of osteoarthritis patients and normal subjects as determined by immunofluorescence. Scale bar = 100 μm. (C) Western blot analysis of IL-1β and cleaved caspase-1 levels in culture SN and pro-IL-1β, pro-caspase-1 and VDR levels in cell lysates in each group. (D) NLRP3 ubiquitination was analyzed in THP-1 cells with different treatments.