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. 2021 Dec 3;14:6523–6542. doi: 10.2147/JIR.S339670

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© 2021 Duan et al.

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Macrophage VDR partly reverses the decrease in chondrogenic migration and inhibits the degradation of ECM proteins and the increase of ECM degradation-associated proteases in chondrocytes caused by NLRP3 activation. (A) Migration of chondrocytes was observed using transwell assay. Scale bar = 200 μm. (B) Images of scratch assays on chondrocytes were obtained under a light field of microscope. (C) The number of migratory cells was calculated and analyzed in each group (n = 3, one-way ANOVA). Scale bar = 200 μm. (D) The healing area of a scratch wound was analyzed in each group (n = 3, one-way ANOVA). (E) Western blot analysis for COL2A1, aggrecan, MMP13 and ADAMTS5. (F) Quantification of the density of immunoreactive bands normalized to tubulin in each group (n = 3, one-way ANOVA). Data are presented as mean ± SD. ns, no significance; *p <0.05; **p <0.01.