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. 2021 Dec 3;14:6523–6542. doi: 10.2147/JIR.S339670

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© 2021 Duan et al.

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1,25VD enhances the inhibitory effect of VDR on the decrease of chondrocyte migration and the decrease of ECM proteins and the increase of ECM degradation-associated proteases caused by NLRP3 activation. (A and B) Migration of chondrocytes was observed and quantified by transwell assay and crystal violet was used to stain migrating chondrocytes (n = 3, one-way ANOVA). Scale bar = 200 μm. (C and D) Images of scratch assays on chondrocytes were obtained under a light microscope and the healing area of a scratch wound was analyzed in each group (n = 3, one-way ANOVA). Scale bar = 200 μm. (E and F) Western blot analysis of COL2A1, aggrecan, ADAMTS5 and MMP13 in chondrocytes were detected and quantified in each group (n = 3, one-way ANOVA). Data are presented as mean ± SD. ns, no significance; *p <0.05; **p <0.01.