Figure 3. Characterization of db/db MD-NOS1KO mouse model.
(A) The blood glucose concentration in db/+ NOS1flox/flox, db/db NOS1flox/flox, db/+ MD-NOS1KO and db/db MD-NOS1KO mice. n=10; *P<0.01 vs db/+. (B) The double immunofluorescence staining of NOS1 and NKCC2 in the kidney slices of db/db NOS1flox/flox and db/db MD-NOS1KO mice. Red: NOS1; Green: NKCC2; Blue: nucleus; Arrow: macula densa. Statistical difference in (A) was calculated by two-way repeated measures ANOVA followed by Sidak multiple comparisons test.