Table 1.

Fractional excretion of Na⁺ (FENa) in diabetic (db/db) and non-diabetic (db/+) MD-NOS1KO as well as NOS1^flox/flox mice.

Groups	UNa (mmol/l)	PCr (mg/dl)	PNa (mmol/l)	UCr (mg/dl)	FENa (%)
db/+ NOS1^flox/flox	125.5±12.0	0.040±0.002	145.2±1.6	47.891±6.848	0.074±0.018
db/+ MD-NOS1KO	122.1±20.0	0.043±0.003	144.4±1.6	52.696±6.129	0.069±0.017
db/db NOS1^flox/flox	30.5±9.1^*	0.020±0.003^*	145.0±2.0	7.366±1.848^*	0.058±0.007^*
db/db MD-NOS1KO	16.3±9.3^*^#	0.025±0.002^*^#	143.9±1.1	7.981±4.909^*	0.036±0.005^*^#

UNa, urinary Na⁺ concentration; PCr, plasma creatinine concentration; PNa, plasma Na⁺ concentration; UCr, urinary creatinine concentration.

P<0.05 vs db/+

P<0.01 vs NOS1^flox/flox.