Comparison 6. Antidepressant plus antipsychotic versus placebo plus antipsychotic.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
6.1 Clinical response	4	447	Risk Ratio (M‐H, Fixed, 95% CI)	1.83 [1.40, 2.38]
6.1.1 Amitriptyline + perphenazine vs perphenazine	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	3.61 [1.23, 10.56]
6.1.2 Fluoxetine + olanzapine vs olanzapine	2	149	Risk Ratio (M‐H, Fixed, 95% CI)	1.64 [1.10, 2.44]
6.1.3 Olanzapine + sertraline vs olanzapine	1	259	Risk Ratio (M‐H, Fixed, 95% CI)	1.76 [1.21, 2.54]
6.2 Dropouts	4	447	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.63, 1.01]
6.2.1 Amitriptyline + perphenazine vs perphenazine	1	39	Risk Ratio (M‐H, Fixed, 95% CI)	3.09 [0.38, 25.19]
6.2.2 Fluoxetine + olanzapine vs olanzapine	2	149	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.59, 1.53]
6.2.3 Olanzapine + sertraline vs olanzapine	1	259	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.53, 0.92]