Comparison 8. Antidepressant plus antipsychotic versus placebo plus the same antidepressant.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
8.1 Clinical response	3	157	Risk Ratio (M‐H, Fixed, 95% CI)	1.70 [1.19, 2.43]
8.2 Dropouts	3	157	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.52, 2.07]
8.2.1 Nortriptyline + perphenazine vs nortriptyline	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.26, 4.81]
8.2.2 Venlafaxine + quetiapine vs venlafaxine	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.33, 2.08]
8.2.3 Amitriptyline + perphenazine vs amitriptyline	1	41	Risk Ratio (M‐H, Fixed, 95% CI)	1.73 [0.35, 8.41]