. 2021 Dec 7;16(12):e0260260. doi: 10.1371/journal.pone.0260260

Table 4. Regression model investigating adjusted associations between socio-demographic and clinical factors and neuropsychological performance.

Socio-demographic clinical predictors	Reference	Variables	Composite Cognitive Score			IHDS			DSF			DSB			AFT			CLOX1			CLOX2
Socio-demographic clinical predictors	Reference	Variables	B	SE	p	B	SE	p	B	SE	p	B	SE	p	B	SE	p	B	SE	p	B	SE	p
Gender	Female	Male	-0.72	0.54	0.19	-0.32	0.28	0.25	-0.19	0.16	0.24	-0.05	0.14	0.71	-0.04	0.40	0.92	-0.12	0.37	0.75	-0.30	0.22	0.16
Age category	18–29 years	30–39	-0.59	0.52	0.26	-0.79	0.28	< .01	0.10	0.15	0.50	-0.03	0.13	0.84	-0.38	0.39	0.33	-0.32	0.37	0.38	0.03	0.21	0.88
Age category	18–29 years	40+	-0.88	0.78	0.26	-0.92	0.41	0.03	0.05	0.23	0.84	-0.07	0.20	0.72	-0.27	0.58	0.64	-0.72	0.55	0.19	0.04	0.32	0.89
Educational attainment	< = Grade 7	Grade 8–11	2.31	0.81	< .01	0.66	0.42	0.12	0.55	0.23	0.02	0.41	0.20	0.04	-0.79	0.60	0.19	1.61	0.56	< .01	0.68	0.33	0.04
Educational attainment	< = Grade 7	Grade 12+	2.88	0.88	< .01	0.36	0.46	0.43	0.70	0.25	< .01	0.53	0.22	0.02	0.38	0.65	0.56	1.86	0.61	< .01	0.55	0.36	0.12
Employment status	Unemployed	Formal sector	-0.33	0.66	0.62	-0.33	0.35	0.35	-0.09	0.20	0.63	0.01	0.17	0.97	-0.94	0.50	0.06	0.20	0.47	0.66	0.24	0.27	0.37
Employment status	Unemployed	Informal sector	-0.14	0.61	0.82	-0.01	0.32	0.97	-0.17	0.18	0.35	-0.03	0.16	0.87	-0.21	0.46	0.65	0.23	0.43	0.59	0.06	0.25	0.80
Substance Use	No	Yes	0.66	0.46	0.15	0.60	0.24	0.01	0.04	0.14	0.76	0.20	0.12	0.08	-0.01	0.34	0.98	0.15	0.32	0.65	0.01	0.19	0.95
Comorbid chronic illness	No	Yes	0.46	0.70	0.52	0.91	0.37	0.01	0.12	0.21	0.57	0.04	0.18	0.84	-1.53	0.53	< .01	0.11	0.49	0.83	0.46	0.28	0.11
Significant Head injury	No	Yes	-1.03	0.97	0.29	-1.24	0.51	0.02	-0.16	0.29	0.59	-0.36	0.25	0.15	-0.12	0.73	0.87	0.14	0.68	0.83	0.22	0.39	0.57
Depression Status	No MDD	MDD	0.37	0.68	0.58	0.03	0.36	0.93	0.02	0.20	0.93	-0.20	0.17	0.25	0.30	0.51	0.55	0.54	0.47	0.25	0.29	0.27	0.29
CRIq score	70–84	85–114	2.40	0.50	< .01	1.42	0.27	< .01	0.20	0.15	0.17	0.32	0.13	0.01	1.41	0.38	< .01	0.59	0.35	0.09	0.41	0.20	0.05
Suspected Infection duration	Infection not suspected	Infected ≤12 months	0.13	0.53	0.80	0.18	0.28	0.52	0.05	0.16	0.77	-0.07	0.13	0.58	0.07	0.40	0.87	0.02	0.37	0.95	0.06	0.21	0.79
Suspected Infection duration	Infection not suspected	Infected > 12 months	-0.14	0.69	0.84	0.16	0.37	0.67	-0.05	0.20	0.81	0.00	0.17	0.98	1.02	0.52	0.05	-0.51	0.48	0.30	-0.44	0.28	0.12
CD4 category	<200	200–499	0.60	0.58	0.30	0.61	0.31	0.05	-0.01	0.17	0.97	0.18	0.15	0.23	0.50	0.43	0.25	-0.14	0.41	0.73	-0.04	0.23	0.85
CD4 category	<200	500+	0.06	0.64	0.92	0.04	0.34	0.90	-0.10	0.19	0.61	-0.05	0.16	0.77	1.00	0.48	0.04	-0.21	0.45	0.64	-0.11	0.26	0.67

IHDS, International HIV Dementia Scale; DSF, Digit Span-Forward; DSB, Digit Span-Backward; AFT, Action Fluency Test; CLOX1, Clock Drawing Test—executive function score; CLOX2, Clock Drawing Test—visuospatial function score; MDD, major depressive disorder; CRIq, Cognitive Reserve Index Questionnaire.