Figure 8.

Exosomal ANXA1 promotes the tumorigenesis of thyroid cancer cells in vivo. (A) Tumor volume was measured every week. (B) Representative images of the xenograft tumors. (C) The tumor weight was measured. (D) Immunohistochemistry of Ki67 and TUNEL assay was used to analyze proliferation and cell apoptosis in the tumor tissues. (E) The protein expression level of p-Smad2, E-cadherin and N-cadherin in tumor tissues were determined using western blot analysis. ^*P<0.05, ^**P<0.01. sh, short hairpin; OE, overexpression; NC, negative control; ANXA1, annexin A1; Exo, exosomes; p, phosphorylated.