Figure 2.

(−)-Epicatechin-induced effects on breast cancer volume. The volume (mm³) obtained 21 days after administration by orthotopic route of 5 × 10³ 4T1 cells is observed in BALB/c mouse. Doxorubicin (DOX) was used as positive control (12 mg/kg), this presented a smaller tumour volume compared with the control. Increasing doses of EC 1, 2 and 3 mg/kg were administered daily during 15 days. Doses of 2 and 3 mg/kg showed a decrease in tumour volume compared with the control and with the dose of 1 mg/kg. Each bar represents the means ± SEM. n = 10. The data were analysed of variance analysis (ANOVA) followed by the Tukey’s multiple comparisons test. P values <0.05 were statistically significant.