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Analysis of Solvent Effects
| solvent | Kd (mM) | EC50 (mM) | ΔTm (°C) |
|---|---|---|---|
| HEPES-buffered saline (HBS) | 0.83 ± 0.27 | 0.84 ± 0.10 | 13.5 ± 0.26 |
| methanol (30% in HBS) | 0.83 ± 0.15 | 0.78 ± 0.17 | 13.5 ± 0.19 |
| DMSO (5 M in HBS) | 0.84 ± 0.20 | 0.85 ± 0.02 | 13.2 ± 0.35 |
ΔTm is in °C. EC50 and Kd are mean values reported in ± SD. Each compound was run on at least two separate plates with n ≥ 4.
