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Nanobodies were assayed for neutralization activity against authentic SARS-CoV-2, with IC50s calculated from neutralization curves.
| ID | Epitope | SARS-CoV-2 IC50(nM) |
|---|---|---|
| S1-1 | RBD | 1.1 |
| S1-4 | RBD | 1310 |
| S1-23 | RBD | 0.7 |
| S1-RBD-4 | RBD | 5.4 |
| S1-RBD-11 | RBD | 3.0 |
| S1-RBD-23 | RBD | 6.1 |
| S2-10 | Non-RBD | 91.2 |
| LaM2 | Non-target ctrl | NA |
NA, no activity.
