Figure 3.

Cellular interactions during muscle regeneration. Schematic of the known interactions between muscle stem cells (MuSC, pink background), fibro-adipogenic progenitors (FAPs, blue background) and immune cells (green background) throughout muscle regeneration. The blue arrows represent molecules secreted by FAPs that act on other cell types, whereas pink and green arrows indicate paracrine factors secreted by muscle stem cells and immune cells, respectively, that affect FAPs. IL, interleukin; WISP1, Wnt1-inducible-signalling pathway protein 1; IGF1, insulin growth factor-1; GDF10, growth differentiation factor 10; TNF-α, tumour necrosis factor alpha; TGF-β, transforming growth factor-β; DAMPs, damage-associated molecular pattern; CCL, C–C motif chemokine ligand; CXCL5, C–X–C motif chemokine ligand 5, PMN, polymorphonuclear cells. This figure was created with the Servier Medical Art service (https://smart.servier.com/), which is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/).