Table 1.
Weight (body and kidney) and biochemical parameters of the different groups.
| Parameter | Young | Sedentary aged | Exercised aged | |
|---|---|---|---|---|
| Weight | Body weight (g) | 187 ± 10.0 | 430 ± 12.4∗∗ | 405 ± 10.0∗∗## |
| Relative kidney weight (g/100 g body weight) | 0.54 ± 0.03 | 0.52 ± 0.01 | 0.53 ± 0.02 | |
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| Kidney function tests | Plasma creatinine (mg/dL) | 0.72 ± 0.06 | 0.82 ± 0.06∗ | 0.77 ± 0.06 |
| Plasma urea (mg/dL) | 40.2 ± 1.8 | 53.6 ± 5.2∗∗ | 45.3 ± 7.1# | |
| Plasma cystatin C (mg/L) | 0.91 ± 0.15 | 2.5 ± 0.28∗∗ | 1.6 ± 0.42∗∗## | |
| Creatinine clearance (mL/min) | 1.27 ± 0.10 | 0.94 ± 0.06∗∗ | 1.02 ± 0.5 | |
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| Oxidative/antioxidative markers | MDA (nmoL/mL) | 5.14 ± 0.99 | 11.39 ± 1.75∗∗ | 8.96 ± 1.60∗∗# |
| TAC (nmoL/L) | 2.49 ± 0.12 | 2.14 ± 0.17∗∗ | 2.44 ± 0.07## | |
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| Inflammatory markers | CRP (mg/L) | 3.20 ± 0.78 | 8.00 ± 1.56∗∗ | 5.20 ± 0.78∗∗## |
| IL-6 (pg/mL) | 148 ± 12.2 | 161 ± 8.9∗ | 152 ± 11.0 | |
Values are presented as mean ± SD (n = 10). ∗indicates P < 0.05; ∗∗indicates P < 0.001 compared with young group; #indicates P < 0.05; ##indicates P < 0.001 compared with sedentary aged group. MDA: malondialdehyde. TAC: total antioxidant capacity. CRP: C-reactive protein. IL-6: interleukin-6.