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. 2021 Nov 30;2021:7681252. doi: 10.1155/2021/7681252

Table 2.

Changes in gene expression of drug metabolizing enzymes and transporters in DSs-treated cells.

Gene symbol Gene title Fold Change
Detoxification: phase I drug
 FMO5 Flavin containing monooxygenase 5 3.42 Down
2.82
3.58
 NCF2 Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2) 4.29 Up
3.88
3.16
Detoxification: phase II and antioxidant proteins
 SQSTM1 Sequestosome 1 2.32 Up
2.46
2.20
 HMOX1 Heme oxygenase (decycling) 1 2.01 Up
2.22
2.65
 GCLC Glutamate-cysteine ligase, catalytic subunit 2.32 Up
2.51
2.49
 GCLM Glutamate-cysteine ligase, modifier subunit 2.36 Up
2.40
2.58
Detoxification: phase III
 SLC2A2 Solute carrier family 2 (facilitated glucose transporter), member 2 2.17 Down
3.24
3.01
 SLC6A6 Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 3.18 Up
3.82
3.17