Table 2.
Changes in gene expression of drug metabolizing enzymes and transporters in DSs-treated cells.
Gene symbol | Gene title | Fold | Change |
---|---|---|---|
Detoxification: phase I drug | |||
FMO5 | Flavin containing monooxygenase 5 | 3.42 | Down |
2.82 | |||
3.58 | |||
NCF2 | Neutrophil cytosolic factor 2 (65 kDa, chronic granulomatous disease, autosomal 2) | 4.29 | Up |
3.88 | |||
3.16 | |||
Detoxification: phase II and antioxidant proteins | |||
SQSTM1 | Sequestosome 1 | 2.32 | Up |
2.46 | |||
2.20 | |||
HMOX1 | Heme oxygenase (decycling) 1 | 2.01 | Up |
2.22 | |||
2.65 | |||
GCLC | Glutamate-cysteine ligase, catalytic subunit | 2.32 | Up |
2.51 | |||
2.49 | |||
GCLM | Glutamate-cysteine ligase, modifier subunit | 2.36 | Up |
2.40 | |||
2.58 | |||
Detoxification: phase III | |||
SLC2A2 | Solute carrier family 2 (facilitated glucose transporter), member 2 | 2.17 | Down |
3.24 | |||
3.01 | |||
SLC6A6 | Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 3.18 | Up |
3.82 | |||
3.17 |