Fig. 6.

Combination treatment with cangrelor + cilostazol has no additional effects on chemokine release. Washed platelets (2 × 10 ⁸ /mL) from healthy volunteers were pretreated with P2Y ₁₂ inhibitor cangrelor, 5 minutes before activation and CCL5 ( A, B ) and CXCL4 ( C, D ) release was determined as described. Platelets were incubated 10 minutes prior to activation with the PDE3 inhibitor cilostazol. Closed circles represent convulxin activation and open circles represent thrombin activation. CTRL: n  = 25–30; Cilo: n  = 6–7; Cangrelor: n  = 4; and Cangr. + Cilo: n  = 4. Median with interquartile range. * p  < 0.05 and ** p  < 0.01, analysis of variance with Sidak test.