Fig. 1.

Schematic representation of the multiple pathways that lead to the activation of coagulation and thrombosis. Direct and indirect mechanisms of endothelial damage contribute to a disruption in the endothelium that would initiate the coagulation cascade. The inflammation caused by COVID-19, which leads to a cytokine storm, is also an important contributor. Other mechanisms are not shown in the figure above, including the role that fibrinolysis and antiphospholipid antibodies play. Created with BioRender