Table 1.
Characteristics of the kidney transplant cohorts depending on their vaccination schedule (heterologous schedule: ChAdOx1-S primed vaccination, then mRNA booster; mRNA exclusive: mRNA vaccine alone)
| Characteristics | Heterologous (n = 28) |
mRNA exclusive (n = 56) |
P value | ||||
|---|---|---|---|---|---|---|---|
| N/A | No. | % | N/A | No. | % | ||
| Positive serology after 3 doses | 0 | 28 | 75.0 | 0 | 56 | 67.8 | 0.32 |
| Male recipient | 0 | 20 | 71.4 | 0 | 39 | 69.6 | 0.99 |
| Transplant rank ≥2a | 0 | 21 | 75.0 | 0 | 46 | 82.1 | 0.56 |
| Calcineurin inhibitor treatment | 0 | 24 | 85.7 | 0 | 44 | 78.5 | 0.56 |
| mTOR inhibitor treatment | 0 | 6 | 12.4 | 0 | 5 | 8.9 | 0.16 |
| Antimetabolite treatment | 0 | 20 | 71.4 | 0 | 40 | 71.4 | 1 |
| Steroid treatment | 0 | 11 | 39.3 | 0 | 22 | 39.3 | 1 |
| N/A | Mean | SD | N/A | Mean | SD | P value | |
|---|---|---|---|---|---|---|---|
| Age, yr | 0 | 58.7 | 13.3 | 0 | 58.7 | 12.0 | 0.99 |
| Time from transplantation, yr | 0 | 8.2 | 6.2 | 0 | 8.5 | 7.4 | 0.79 |
| Lymphocyte count, /mm3 | 0 | 1750 | 750 | 0 | 1730 | 1000 | 0.52 |
| Anti-spike IgG titer, BAU/ml | 1 | 159 | 110 | 0 | 125 | 116 | 0.36 |
| Allograft function by MDRD, ml/min | 0 | 44.6 | 18.0 | 0 | 51.5 | 19.2 | 0.06 |
BAU, binding antibody unit; MDRD, Modification of Diet in Renal Disease; N/A, nonavailable data.
a
Transplant rank ≥2: patient having received a second or more transplant kidney.