Figure 7.

Expression of mitochondrial ribosomal proteins (MRPs) is downregulated under hypoxia. (A) RNA expression of MRPs involved in mtRNA translation in MCF7 cells cultured in normoxia or 0.1% hypoxia for 4h, 8h, 16h, 24h and 48h was evaluated by qPCR (n=3). (B) MRPs mRNA expression in 786-0 WT and 786-0 KO cells cultured in normoxia or 0.1% hypoxia for 48h was also evaluated by qPCR (n=3). Number of replicates indicate biological replicates and data is shown as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.