Table 3.

Summary of treatment response

	Regimen M Afatinib (20 mg) + TMZ + RT N = 7	Regimen M Afatinib (30 mg) + TMZ + RT N = 6	Regimen M Afatinib (40 mg) + TMZ + RT N = 7	Regimen M Afatinib (total) + TMZ + RT N = 20
Best overall response, n (%)
CR	0	1 (17)	0	1 (5)
PR	2 (29)	2 (33)	0	4 (20)
SD	5 (71)	2 (33)	4 (57)	11 (55)
PD	0	1 (17)	1 (14)	2 (10)
Missing	0	0	2 (29)	2 (10)
Objective response, n (%)	2 (29)	3 (50)	0	5 (25)
Disease control rate, n (%)	7 (100)	5 (83)	4 (57)	16 (80)

	Regimen U afatinib (20 mg) + RT N = 3	Regimen U afatinib (40 mg) + RT N = 13	Regimen U afatinib (total) + RT N = 16
Best overall response, n (%)
CR	0	0	0
PR	0	1 (8)	1 (6)
SD	1 (33)	7 (54)	8 (50)
PR	2 (67)	3 (23)	5 (31)
Missing	0	2 (15)	2 (13)
Objective response, n (%)	0	1 (8)	1 (6)
Disease control rate, n (%)	1 (33)	8 (62)	9 (56)

CR complete response, PD progressive disease, PR partial response, RT radiotherapy, SD stable disease, TMZ temozolomide