Table 1.
General patient characteristics and comparative analysis between ioUS and combined ioMRI + ioUS groups
| Characteristics | Total | IoUS | ioUS+IoMRI | P value |
|---|---|---|---|---|
| Age in Years (Mean ± SD) | 75.98 ± 4.99 | 80.16 ± 5.99 | 74.43 ± 3.36 | 0.0053 |
| Gender | ||||
| Female | 20 | 3 (23.08%) | 17 | 0.188 |
| Male | 28 | 10 (76.92%) | 18 | |
| Presentation | ||||
| Altered mental status | 17 (35.42%) | 5 (38.46%) | 12 (34.29 %) | 1 |
| Facial strength | 9 (18.75%) | 2 (15.38%) | 7 (20 %) | 1 |
| Language/Speech deficit | ||||
| Seizures | 5 (10.42%) | 2 (15.38%) | 3 (8.57%) | 0.602 |
| Motor deficit and Ataxia | 16 (33.33%) | 6 (46.15%) | 10 (28.57%) | 0.311 |
| Visual field cut | 10 (20.83%) | 1 (7.69%) | 9 (25.71%) | 0.248 |
| Past medical history | 44 (91.67%) | 12 (92.31%) | 32 (91.43%) | 1 |
| Hypertension | 27 (56.25%) | 7 (53.85%) | 20 (57.14%) | 1 |
| Diabetes Mellitus | 9 (18.75%) | 1 (7.69%) | 8 (22.86%) | 0.411 |
| Hyperlipidemia | 23 (47.92%) | 6 (46.1 %) | 17 (48.57%) | 1 |
| Thyroid disorder | 5 (10.42%) | 0 | 5 (14.29%) | 0.304 |
| DVT/PE | 4 (8.33%) | 1 (7.69 %) | 3 (8.57%) | 1 |
| Cardiovascular Disorders | 17 (35.42 %) | 8 (61.54 %) | 9 (25.71%) | 0.039 |
| Arrhythmia | 9 (18.75 %) | 4 (30.77 %) | 5 (14.29%) | 0.228 |
| Stroke | 4 (8.33 %) | 2 (15.38 %) | 2 (5.71%) | 0.294 |
| CAD | 4 (8.33%) | 2 (15.38%) | 2 (5.71%) | 0.294 |
| Aortic aneurysm | 3 (6.25%) | 3 (23.08%) | 0 | 0.017 |
| Aortic stenosis | 2 (4.16%) | 1 (7.69%) | 1 (2.86%) | 0.473 |
| Localization | ||||
| Right | 32 (66.67%) | 7 (53.85%) | 25 (71.43%) | 0.311 |
| Left | 16 (33.33%) | 6 (46.15%) | 10 (28.57%) | |
| Anatomic classification | ||||
| Supratentorial | 47 (97.92%) | 13 (100%) | 34 (97.14%) | 1 |
| Infratentorial | 1 (2.08%) | 0 | 1 (2.86%) | |
| Location | ||||
| Frontal | 15 (31.25 %) | 4 (30.77%) | 11 (31.43%) | 1 |
| Temporal | 22 (45.83 %) | 6 (46.15%) | 16 (45.71%) | 1 |
| Parietal | 16 (33.33 %) | 5 (38.46%) | 11 (31.43%) | 0.735 |
| Occipital | 3 (6.25%) | 1 (7.69%) | 2 (5.71%) | 1 |
| Multilobar | 8 (16.67%) | 3 (23.08%) | 5 (14.29%) | 0.665 |
| Multifocal | 1 (2.08 %) | 1 (7.69%) | 0 | 0.271 |
| Eloquent structure involvement | 16 (33.33 %) | 5 (38.46%) | 11 (31.43%) | 0.735 |
| Basal Ganglia | 6 (12.50%) | 3 (23.08%) | 3 (8.57%) | 0.323 |
| Insula | 8 (16.67%) | 1 (7.69%) | 7 (20%) | 0.418 |
| Thalamus | 3 (6.25%) | 2 (15.38%) | 1 (2.86%) | 0.265 |
| Motor cortex | 1 (2.08%) | 1 (7.69%) | 0 | 0.271 |
| Large arterial encasement by the tumor | 1 (2.08 %) | 0 | 1 (2.86%) | 1 |
| Brainstem | 1 (2.08%) | 0 | 1 (2.86%) | 1 |
| Corpus callosum | 0 | 0 | 0 | NA |
| Median tumor volume | 27.35 | 24.35 | 34.25 | 0.1454 |
| MGMT status | ||||
| Methylated | 17 (36.17%) | 3 (6.38%) | 14 (29.79%) | 1* |
| Partially methylated | 6 (12.77%) | 3 (6.38%) | 3 (6.38%) | |
| Non-Methylated | 24 (51.06%) | 6 (12.77%) | 18 (36.30%) |
Bold values indicate statistical significance at the p < 0.05 level
*Methylated and partially methylated MGMT have been grouped together for the comparative analysis
DVT Deep venous thrombosis, PE Pulmonary embolus