TABLE 4.
Summary of the differential metabolites identified in the serum of three Groups.
| No. | Rt (min) | m/z | Formula | Metabolites | VIP | FC | Trend | Pathway | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| M vs. C | G vs. M | M vs. C | G vs. M | ||||||||
| 1 | 5.42 | 260.19 | C13H25NO4 | Hexanoylcarnitine | 1.68 | 0.21 | 3.28 | ↓## | ↑** | — | |
| 2 | 6.29 | 288.22 | C15H29NO4 | L-Octanoylcarnitine | 1.63 | 0.22 | 1.27 | ↓## | ↑ | — | |
| 3 | 6.83 | 316.25 | C17H33NO4 | Decanoylcarnitine | 1.60 | 2.16 | 0.70 | ↑## | ↓** | — | |
| 4 | 13.95 | 395.39 | C26H52O2 | Hexacosanoic acid | 1.08 | 5.53 | 0.79 | ↑## | ↓ | — | |
| 5 | 13.17 | 381.37 | C25H50O2 | Pentacosanoic acid | 1.07 | 0.53 | 0.79 | ↓## | ↓ | — | |
| 6 | 7.70 | 400.34 | C23H45NO4 | L-Palmitoylcarnitine | 1.07 | 2.09 | 0.76 | ↑## | ↓* | — | |
| 7 | 0.90 | 132.08 | C4H9N3O2 | Creatine | 1.07 | 0.68 | 1.32 | ↓## | ↑** | b | |
| 8 | 0.86 | 162.11 | C7H15NO3 | L-Carnitine | 1.06 | 0.70 | 1.27 | ↓## | ↑ | — | |
| 9 | 0.86 | 126.02 | C2H7NO3S | Taurine | 1.06 | 0.66 | 1.29 | ↓## | ↑ | d | |
| 10 | 9.10 | 524.37 | C26H54NO7P | LysoPC(18:0) | 1.03 | 1.26 | 0.79 | ↑## | ↓** | a | |
| 11 | 13.08 | 786.60 | C44H84NO8P | PC (18:0/18:2 (9Z,12Z)) | 1.04 | 0.72 | 1.33 | ↓# | ↑* | a, c, e, f | |
| 12 | 9.03 | 327.23 | C22H32O2 | Docosahexaenoic acid | 1.06 | 0.66 | 1.34 | ↓## | ↑** | — | |
| 13 | 12.24 | 746.57 | C41H80NO8P | PE (18:0/18:1 (9Z)) | 1.05 | 1.68 | 0.69 | ↑## | ↓** | a | |
| 14 | 0.90 | 116.07 | C5H9NO2 | L-Proline | 1.06 | 0.57 | 1.40 | ↓## | ↑** | b | |
| 15 | 8.88 | 277.22 | C18H30O2 | Alpha-Linolenic acid | 1.07 | 0.60 | 1.57 | ↓# | ↑** | — | |
| 16 | 9.13 | 279.23 | C18H32O2 | Linoleic acid | 1.08 | 0.76 | 1.29 | ↓# | ↑* | f | |
| 17 | 8.80 | 438.30 | C21H44NO6P | PE (P-16:0e/0:0) | 1.09 | 1.73 | 0.73 | ↑## | ↓** | — | |
| 18 | 11.58 | 365.34 | C24H46O2 | Nervonic acid | 1.08 | 0.78 | 1.55 | ↓## | ↑** | — | |
| 19 | 8.85 | 227.20 | C14H28O2 | Myristic acid | 1.09 | 1.91 | 0.79 | ↑## | ↓ | — | |
| 20 | 9.09 | 303.23 | C20H32O2 | Arachidonic acid | 1.11 | 2.09 | 0.77 | ↑## | ↓** | c | |
| 21 | 9.45 | 281.25 | C18H34O2 | Oleic acid | 1.44 | 1.44 | 0.73 | ↑## | ↓** | e | |
| 22 | 11.03 | 704.52 | C38H74NO8P | PC (16:1 (9Z)/14:0) | 1.43 | 0.58 | 1.29 | ↓# | ↑* | — | |
| 23 | 9.62 | 307.26 | C20H36O2 | Eicosadienoic acid | 1.65 | 4.27 | 0.54 | ↑## | ↓** | — | |
| 24 | 9.47 | 331.26 | C22H36O2 | Adrenic acid | 1.65 | 4.58 | 0.74 | ↑## | ↓ | — | |
Control, model, and geniposide groups (n = 6 per group). # p < 0.05 and ## p < 0.01, Model group vs. Control group; ∗ p < 0.05 and ∗∗ p < 0.01, Geniposide group vs. Model group.
(a) Glycerophospholipid metabolism, (b) Arginine and proline metabolism, (c) AA metabolism, (d) Taurine and hypotaurine metabolism, (e) alpha-Linolenic acid metabolism, and (f) Linoleic acid metabolism.