Table 2.

Impact of patient selection criteria on the positive predictive value and relative sensitivity for p53 screening in childhood cancer (Adapted from Chompret et al. [58].).

Degree of stringency	Criterion	Positive predictive value	Relative sensitivity
Very lenient	At least one first or second degree relative affected by any type of cancer.	6% (14/223)	93% (14/15)
Lenient	As above but neoplasms in the affected relatives restricted to the following types: sarcoma, brain tumours, breast cancer, adrenocortical carcinoma, haematological malignancies, stomach cancer, melanoma and germ cell tumours.	9% (13/141)	87% (13/15)
Stringent	As above but tumour types further restricted to sarcomas, brain tumours, breast cancer and adrenocortical carcinoma.	15% (12/81)	80% (12/15)
Very stringent	As above but the affected relative(s) must have been diagnosed before age 46 or, if sarcoma, at any age.	43% (9/21)	60% (9/15)