Table 1.

The effect of niosomal formulation contain crocin on I/R-induced morphological changes followed by 1 h and 24 h of reperfusion.

Groups	Reduction size of	Necrosis	Medullary vascular cogestion	Inflammation	Tubular cast
Control 1 h	0.4	0	0.6	0	0
I/R 1 h	1	0.8*	1.4	1	0
I/R empty noisome	0.8	0.8*	1.8	0.8*	0
I/R crocin noisome	0.4	0.4	1.8	1	0
Control 24 h	0	0	1	0	0
I/R 24 h	1.5**	1	1.8	1.5**	2**
I/R empty 24 h noisome	1.4**	0.6	2.2**	1.6**	2**
I/R crocin 24 h noisome	1	0.5	1**	0.5+	1.5

*P < 0.05, **P < 0.01 versus control; ⁺P < 0.05 versus I/R and I/R + empty niosome group.