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. 2021 Dec 7;12:7104. doi: 10.1038/s41467-021-27326-0

Fig. 4. Immunity cell composition across PAH transcriptomic subgroups.

Fig. 4

a CIBERSORT estimation of relative cell abundance in patients of subgroups I (n = 129), II (n = 112) and V (n = 89) using two-sided test and Bonferroni adjusted mean difference significance notation with p values: pI-II(Dendritic cells activated) = 0.011, pI-II(Neutrophils) = 4.4 × 10−11, pI-V(Neutrophils) = 2.0 × 10−3, pII-V(Neutrophils) = 1.7 × 10−3, pI-II(T cells CD8) = 4.8 × 10−5, pI-II(T cells CD4 naive) = 1.9 × 10−8, pI-V(T cells CD4 naive) =  3.8 × 10−3, pI-II(T cells CD4 memory resting) = 2.3 × 10−5, pI-II(B cells naive) = 2 × 10−5, pI-II(B cells memory) = 2.5 × 10−6, pI-V(B cells memory) = 3.9 × 10−3, pI-II(Plasma cells) = 6.4 × 10−4, pII-V(Plasma cells) = 6.5 × 10−5 and pI-II(Monocytes) = 0.0053. Vertical centre line represents the median, top and bottom bounds of the box represent the first and third quartile, while the tips of the whiskers represent min and max values. b Whole-blood cell counts across subgroups I (n = 129), II (n = 112) and V (n = 89) using two-sided test and Bonferroni adjusted mean difference significance notation. pI-II (Neutrophils) = 7.2 × 10−12, pI-V (Neutrophils) = 8.0 × 10−4, pII-V (Neutrophils) = 4.4 × 10−4, pI-II (Neutrophils/Lymphocytes) = 0.0061 and pI-II (monocytes) = 0.0076. Vertical centre line represents the median, top and bottom bounds of the box represent the first and third quartile, while the tips of the whiskers represent min and max values. c Proportion of patients in each subgroup with DNA variants in HLA-DPA1/DPB1 (rs2856830), SOX17 (rs10106467 and rs13266183, homozygous and heterozygous), BMPR2 (rare pathogenic variant). Notably, pI-II (HLA-DPA1/DPB1) = 0.009. Generated using a two-sample test for equality of proportions with continuity correction. *P value ≤ 0.05, **p value ≤ 0.01, ***p value ≤ 0.001.