Table 1.

Clinical illustration of BRCAPANCPRO for a hypothetical family shown in Fig. 1.

	Carrier probability (%)			Counselee’s absolute risk of developing cancer (%)a
				By age 65 years			By age 85 years
	PANC	BRCA2	BRCA1	PC	BC	OC	PC	BC	OC
As shown (counselee’s sister affected with breast cancer at 45 years and paternal grandfather with pancreatic cancer at 75 years)	1.6	0.42	0.14	0.33	3.1	0.28	1.9	11.1	0.94
As shown, and paternal aunt has pancreatic cancer at age 60 years	13.6	0.49	0.11	1.3	3.1	0.29	5.2	11.2	0.96
As shown, and paternal aunt has breast cancer at age 60 years	1.6	1.4	0.34	0.34	3.4	0.41	1.9	11.7	1.4
As shown, and paternal aunt has ovarian cancer at age 60 years	1.4	4.2	2.7	0.36	4.5	1.2	2.2	14.2	3.6
As shown, and paternal aunt has ovarian cancer at age 60 years and other paternal aunt has breast cancer at 55 years	0.98	10.7	5.7	0.41	6.5	2.5	2.6	19	7.4
As shown, and paternal aunt has pancreatic cancer at age 60 years and other paternal aunt has breast cancer at 55 years	12.9	2	0.33	1.3	3.5	0.48	5.2	12.1	1.6

Diagnoses of breast, pancreas, and ovarian cancer are varied to show model behaviour. Rows correspond to variations on the pedigree.

PC pancreatic cancer, BC breast cancer, OC ovarian cancer.

^aAssuming counselee has not developed any of these cancers before age 55 years.