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. 2021 Dec 7;12:7092. doi: 10.1038/s41467-021-27318-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Differential proteomic profiling of SARS-CoV-2-infected nasal ALI cultures. Mass spectrometry-based proteomics was carried out on whole-cell lysates prepared at 72 h post infection (hpi; n = 6 donors per condition). The exact adjusted (adj) P values can be found in Supplementary dataset 5. a Volcano plot illustrating 180 differentially expressed proteins with increased (orange points) and decreased (purple points) expression in infected as compared to mock-infected samples. Dotted red lines indicate those proteins with a fold change of >1.5 and adjusted p values <0.05. b Principal component (PC) analysis of the whole proteome dataset. c Functional annotation network of differentially expressed proteins to indicate those proteins with a fold change (FC; Log2).