Fig. 2. Effects of 5-aza-dC on tumour growth.

a Dose-response curves of the seven neuroblastoma cell lines to 5-aza-dC. Data are shown as the mean ± SD obtained from three experiments (left). The IC₅₀ values of the seven neuroblastoma cell lines to 5-aza-dC (right). Treatment with 5-aza-dC induced a growth-suppressive effect in a dose-dependent manner. b Xenograft growth curves of the 5-aza-dC- and mock-treated groups. Results are shown as mean ± SE, and statistical significance was tested using an unpaired Student’s t-test (n = 5/vehicle group; n = 6/5-aza-dC group). c Macroscopic view of the xenografts in the two treatment groups. d The therapeutic effect assessed by tumour weight at necropsy. Horizontal bars show the average. The tumour size was consistently small even though there were no significant differences in the average tumour weight between vehicle- and 5-aza-dC-treated groups.